1-Bromo-3-chloropropane → HCID 13912832, 화합물
반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][C:3]=1[OH:10].Br[CH2:12][CH2:13][CH2:14][Cl:15].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][C:3]=1[O:10][CH2:12][CH2:13][CH2:14][Cl:15]참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
A mixture of 2-chloro-4-cyanophenol (2.15 g), 3-bromo-1-chloropropane (2.3 g), dimethylformamide (3 ml) and potassium carbonate (1.5 g) was heated at 100° C. for one hour. The inorganic salt was then filtered off and the solvent was distilled off. The residue was dissolved in chloroform, chromatographed on a column of silica gel (80 g), and eluted with a solution of petroleum ether-ethyl acetate (10:1) to give 3-(2-chloro-4-cyanophenoxy)propyl chloride as a colorless oil (3.06 g).
후처리
- filtrationThe inorganic salt was then filtered off
- distillationthe solvent was distilled off
- dissolutionThe residue was dissolved in chloroform
- customchromatographed on a column of silica gel (80 g)
- washeluted with a solution of petroleum ether-ethyl acetate (10:1)
출처 및 근거
- ORD 기록
- ord-1d490680f71445f294f8123e100d186e
- 출처 데이터셋
- uspto-grants-1987_06
- 특허 번호
- US04672073
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