3,4-dihydro-2H-pyran → 2-(3-iodopropoxy)tetrahydro-2H-pyran

HRID 652461

반응식

HRID 652461 반응식
[I:1][CH2:2][CH2:3][CH2:4][OH:5].[O:6]1[CH:11]=[CH:10][CH2:9][CH2:8][CH2:7]1.C1C=CC(N=NC2C=CC(N)=NC=2N)=CC=1.Cl.CC1C=CC(S(O)(=O)=O)=CC=1>ClCCl>[I:1][CH2:2][CH2:3][CH2:4][O:5][CH:7]1[CH2:8][CH2:9][CH2:10][CH2:11][O:6]1

참가 물질

5

반응물 3

HCID 80803,4-dihydro-2H-pyranHCID 693903-Iodo-1-propanolHCID 21909214Pyridium p-toluenesulfonate

생성물 1

HCID 110329072-(3-iodopropoxy)tetrahydro-2H-pyran

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 3-iodopropanol (15 g, 80.65 mole), dihydropyran (14.7 ml, 161.29 mole) and pyridium p-toluenesulfonate (500 g, 2.0 mole) in 100 ml of dry dichloromethane was stirred at room temperature under an atmosphere of nitrogen for 2.5 hours. The resulting mixture was diluted with dichloromethane (150 ml), washed with water and a saturated sodium bicarbonate solution, dried over anhydrous magnesium sulfate and evaporated in vacuo. The residue was flash chromatographed on a silica gel to give 20.43 g of the title A compound as an oil.

후처리

  1. washwashed with water
  2. dry with materiala saturated sodium bicarbonate solution, dried over anhydrous magnesium sulfate
  3. customevaporated in vacuo
  4. customchromatographed on a silica gel

출처 및 근거

ORD 기록
ord-39108c3189d14463b393a5bf0ef51f59
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04672075

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