Sodium Hydroxide → (4-Acetyl-3-hydroxy-2-propylphenoxy)acetic acid

HRID 652502노트

반응식

HRID 652502 반응식
C([O:3][C:4](=[O:20])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[C:9]([OH:16])[C:8]=1[CH2:17][CH2:18][CH3:19])C.[OH-].[Na+]>CO>[C:13]([C:10]1[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([OH:20])=[O:3])=[C:8]([CH2:17][CH2:18][CH3:19])[C:9]=1[OH:16])(=[O:15])[CH3:14]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 13389144Ethyl (4-acetyl-3-hydroxy-2-propylphenoxy)acetate

생성물 1

HCID 13753869(4-Acetyl-3-hydroxy-2-propylphenoxy)acetic acid수율 82.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 5.6 g of (4-acetyl-3-hydroxy-2-propylphenoxy)acetic acid ethyl ester in 50 ml of methanol was added 50 ml of 1.0N sodium hydroxide and the solution was stirred at reflux for 2 hours. The methanol was removed in vacuo, the residue was acidified and the product was extracted with ether. The dried (over magnesium sulfate) extract was concentrated in vacuo to a solid which was recrystallized from ether-hexane to give 4.18 g of (4-acetyl-3-hydroxy-2-propylphenoxy)acetic acid, the titled compound, mp 128°-130°, (83% yield).

후처리

  1. temperatureat reflux for 2 hours
  2. customThe methanol was removed in vacuo
  3. extractionthe product was extracted with ether
  4. dry with materialThe dried (over magnesium sulfate)
  5. extractionextract
  6. concentrationwas concentrated in vacuo to a solid which
  7. customwas recrystallized from ether-hexane

출처 및 근거

ORD 기록
ord-6e24e712a5d54b51bda708d08bd1aee4
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04672066

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