Water → Levamisole

HRID 652556

반응식

HRID 652556 반응식
[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]2[N:14]=[C:13]3[N:9]([CH2:10][CH2:11][S:12]3)[CH2:8]2)=[CH:5][CH:6]=1.O>CC(=O)C>[CH:1]1[CH:6]=[CH:5][C:4]([C@@H:7]2[N:14]=[C:13]3[N:9]([CH2:10][CH2:11][S:12]3)[CH2:8]2)=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 962WaterHCID 3913Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-

생성물 1

HCID 26879Levamisole수율 116.9%

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
15 °C

실험 절차

To a refluxing solution of 20.43 g of tetramisole (0.1 mol) in 190 ml of 2-propanone and 10 ml. of water was added 15.9 g of L-N-[(4-methoxyphenyl)sulfonyl]glutamic acid (0.05 mol). The mixture was refluxed for another 5 minutes and cooled to 15° C. After 12 hours the precipitate was filtered off, washed with 2-propanone and dried under vacuo at 70° C., yielding 23.88 g of levamisole.L-N-[(4-methoxyphenyl)sulfonyl]glutamic acid (salt) (yield=91.6%) αD20 =-63.5° (c5, 1N HCl); mp. 127.6°-129.3° C.

후처리

  1. temperatureThe mixture was refluxed for another 5 minutes
  2. filtrationAfter 12 hours the precipitate was filtered off
  3. washwashed with 2-propanone
  4. customdried under vacuo at 70° C.

출처 및 근거

ORD 기록
ord-9ada5955cb59420d9a38cff60d0bad85
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04672126

연결된 노트

불러오는 중…