Thionyl Chloride → 2-Methoxy-3-isopropyl-5-sulphamoyl-6-methylbenzoyl chloride

HRID 652757노트

반응식

HRID 652757 반응식
[CH3:1][O:2][C:3]1[C:11]([CH:12]([CH3:14])[CH3:13])=[CH:10][C:9]([S:15](=[O:18])(=[O:17])[NH2:16])=[C:8]([CH3:19])[C:4]=1[C:5](O)=[O:6].S(Cl)([Cl:22])=O>CN(C)C=O.C(Cl)(Cl)Cl>[CH3:1][O:2][C:3]1[C:11]([CH:12]([CH3:14])[CH3:13])=[CH:10][C:9]([S:15](=[O:18])(=[O:17])[NH2:16])=[C:8]([CH3:19])[C:4]=1[C:5]([Cl:22])=[O:6]

참가 물질

5

반응물 2

HCID 24386Thionyl Chloride2회HCID 201968382-Methoxy-3-isopropyl-5-sulphamoyl-6-methylbenzoic acid

생성물 1

HCID 201968202-Methoxy-3-isopropyl-5-sulphamoyl-6-methylbenzoyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6212Chloroform용매

실험 절차

72 g of 2-methoxy-3-isopropyl-5-sulphamoyl-6-methylbenzoic acid (0.25 mole), 250 ml of chloroform, 23 ml of thionyl chloride and 3 drops of dimethylformamide are placed in a 1 liter flask fitted with an agitator and a condenser. The mixture is heated to reflux for 1.5 hours, then 18 ml of thionyl chloride is added and the reflux is continued for 1.5 hours. The solids dissolve completely.

후처리

  1. customfitted with an agitator and a condenser
  2. temperatureThe mixture is heated
  3. temperatureto reflux for 1.5 hours
  4. dissolutionThe solids dissolve completely

출처 및 근거

ORD 기록
ord-d2d56191e7bf4e59bfa653ea03ba0440
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04673686

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