Isopropanol → HCID 20195166, 화합물

HRID 652992노트

반응식

HRID 652992 반응식
[Na].Cl[C:3]1[CH:8]=[C:7](Cl)[N:6]=[C:5]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)[N:4]=1.[CH:17]([OH:20])([CH3:19])[CH3:18]>>[C:13]1([CH3:16])[CH:14]=[CH:15][C:10]([C:5]2[N:6]=[C:7]([O:20][CH:17]([CH3:19])[CH3:18])[CH:8]=[C:3]([O:20][CH:17]([CH3:19])[CH3:18])[N:4]=2)=[CH:11][CH:12]=1

참가 물질

4

반응물 3

HCID 3776IsopropanolHCID 5360545SodiumHCID 12703697HCID 12703697, 화합물

생성물 1

HCID 20195166HCID 20195166, 화합물

실험 절차

21.16 g of sodium are dissolved in anhydrous isopropanol and to this solution are added 95.64 g of 4,6-dichloro-2-p-tolylpyrimidine at 60°-65° C. over 15 minutes. The mixture is then heated to the boil and refluxed for a further 4 hours to bring the reaction to completion. Excess isopropanol is then distilled off and the residual oil is taken up in chloroform. The chloroform layer is washed with water, dried over sodium sulfate, and filtered. The solvent is then distilled off, affording 112 g of 2-p-tolyl-4,6-bis-isopropoxypyrimidine in the form of a yellowish oil which is purified by high vacuum distillation. The boiling point is 123° C./5.332 Pascal.

후처리

  1. temperatureThe mixture is then heated to the boil
  2. temperaturerefluxed for a further 4 hours
  3. customthe reaction to completion
  4. distillationExcess isopropanol is then distilled off
  5. washThe chloroform layer is washed with water
  6. dry with materialdried over sodium sulfate
  7. filtrationfiltered
  8. distillationThe solvent is then distilled off

출처 및 근거

ORD 기록
ord-e1ab474c78db4f5a86f686416ce0396d
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04674229

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