3-(2-Oxo-1,2,3,4-tetrahydroquinolin-3-yl)propanoic acid → HCID 13519806, 화합물

HRID 653430노트

반응식

HRID 653430 반응식
[O:1]=[C:2]1[CH:11](CCC(O)=O)[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1>C(OC(=O)C)(=O)C>[CH2:10]1[C:9]2=[CH:8][CH:7]=[CH:6][C:5]3=[C:4]2[N:3]([C:2](=[O:1])[CH2:11][CH2:10]3)[C:2](=[O:1])[CH2:11]1

참가 물질

3

반응물 1

HCID 162275833-(2-Oxo-1,2,3,4-tetrahydroquinolin-3-yl)propanoic acid

생성물 1

HCID 13519806HCID 13519806, 화합물

시약·촉매·용매 1

HCID 7918Acetic Anhydride용매

반응 조건

온도
100 °C

실험 절차

1,2,3,4-Tetrahydro-2-oxo-3-quinolinepropanoic acid (2.1 g, 0.0096 mole) is dissolved in acetic anhydride (10 ml) and the solution is heated to 100° C. for one hour. Excess acetic anhydride is removed at reduced pressure and the residual anhydride is removed by addition of toluene and repeated concentration. The solid is recrystallized from ethyl acetate to yield pure 1,2,6,7-tetrahydro-3H,5H-benzo[ij]quinolizine-3,5-dione, mp 136°-140° C.

후처리

  1. customExcess acetic anhydride is removed at reduced pressure
  2. customthe residual anhydride is removed by addition of toluene
  3. concentrationconcentration
  4. customThe solid is recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-f519d34ee95c48e08da8237f2541d28e
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04677112

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