Benzyl Alcohol → HCID 20194697, 화합물

HRID 653431노트

반응식

HRID 653431 반응식
[CH2:1]1[C:10]2=[CH:11][CH:12]=[CH:13][C:8]3=[C:9]2[N:4]([C:5](=[O:14])[CH2:6][CH2:7]3)[C:3](=[O:15])[CH2:2]1.Cl.[C:17]1([CH2:23][OH:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:17]1([CH2:23][O:24][C:3](=[O:15])[CH2:2][CH2:1][C:10]2[CH:11]=[CH:12][CH:13]=[C:8]3[C:9]=2[NH:4][C:5](=[O:14])[CH2:6][CH2:7]3)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

4

반응물 3

HCID 244Benzyl AlcoholHCID 313Hydrochloric AcidHCID 13519806HCID 13519806, 화합물

생성물 1

HCID 20194697HCID 20194697, 화합물

실험 절차

A solution of 1,2,6,7-tetrahydro-3H,5H-benzo[ij]-quinolizine-3,5-dione (20.1 g, 0.1 mole) in phenylmethanol (200 ml) is treated with a drop of concentrated hydrochloric acid. The mixture is refluxed 24 hours (or until the starting dione can no longer be detected by thin layer chromatography). The solution is cooled and concentrated at reduced pressure. The product is purified by flash chromatography to yield 1,2,3,4-tetrahydro-2-oxo-8-quinoline propanoic acid phenylmethyl ester.

후처리

  1. temperatureThe mixture is refluxed 24 hours (or until the starting dione
  2. temperatureThe solution is cooled
  3. concentrationconcentrated at reduced pressure
  4. customThe product is purified by flash chromatography

출처 및 근거

ORD 기록
ord-846f941e5d60449dbdb53eae21814fae
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04677112

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