Benzyl Bromide → 3-Benzyl-5-bromo-2-ethyl-7-methylimidazo[4,5-b]pyridine

HRID 653641노트

반응식

HRID 653641 반응식
[Br:1][C:2]1[N:7]=[C:6]2[N:8]=[C:9]([CH2:11][CH3:12])[NH:10][C:5]2=[C:4]([CH3:13])[CH:3]=1.[H-].[Na+].[CH2:16](Br)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>CN(C=O)C>[CH2:16]([N:8]1[C:6]2=[N:7][C:2]([Br:1])=[CH:3][C:4]([CH3:13])=[C:5]2[N:10]=[C:9]1[CH2:11][CH3:12])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 24758Sodium hydrideHCID 193856485-Bromo-2-ethyl-7-methyl-1H-imidazo[4,5-b]pyridine

생성물 1

HCID 193856613-Benzyl-5-bromo-2-ethyl-7-methylimidazo[4,5-b]pyridine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 10 g (39 mmol) of the product of Step C in DMF (70 mL) at rt was added NaH (1.3 g of an 80% oil dispersion, 43 mmol). After 20 minutes benzyl bromide (5.15 mL, 43 mmol) was added and the reaction was stirred for 16 hours. The mixture was poured onto 500 g of ice and the solid residue was filtered, washed with water and air dried to give the title compound.

후처리

  1. filtrationthe solid residue was filtered
  2. washwashed with water and air
  3. customdried

출처 및 근거

ORD 기록
ord-e4c98d7ae65d4591b849fe96912872a0
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05128327

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