Sodium Hydroxide → 2-[N-(2,4,6-trifluorophenyl)sulfamoyl] acetic acid

HRID 654007

반응식

HRID 654007 반응식
C[O:2][C:3](=[O:18])[CH2:4][S:5](=[O:17])(=[O:16])[NH:6][C:7]1[C:12]([F:13])=[CH:11][C:10]([F:14])=[CH:9][C:8]=1[F:15].[OH-].[Na+]>O1CCOCC1>[F:15][C:8]1[CH:9]=[C:10]([F:14])[CH:11]=[C:12]([F:13])[C:7]=1[NH:6][S:5]([CH2:4][C:3]([OH:18])=[O:2])(=[O:17])=[O:16]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 150576002-[N-(2,4,6-trifluorophenyl)sulfamoyl]-acetic acid methyl ester

생성물 1

HCID 150576012-[N-(2,4,6-trifluorophenyl)sulfamoyl] acetic acid

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

1.37 g (4.8 mmol) of 2-[N-(2,4,6-trifluorophenyl)sulfamoyl]-acetic acid methyl ester is dissolved in 15 ml of dioxane, 7.5 ml of 2N sodium hydroxide solution is added and it is stirred for one hour at room temperature. The solution is then evaporated to dryness, the residue is dissolved in water, the solution is acidified with 2N hydrochloric acid and extracted twice with ethyl acetate. The ethyl acetate extract is dried on magnesium sulfate, filtered and evaporated to dryness. The residue is crystallized from diethyl ether. 1.12 g (4.16 mmol)=86.68% of the theoretical yield is obtained. Melting point 126-127° C.

후처리

  1. customThe solution is then evaporated to dryness
  2. dissolutionthe residue is dissolved in water
  3. extractionextracted twice with ethyl acetate
  4. extractionThe ethyl acetate extract
  5. customis dried on magnesium sulfate
  6. filtrationfiltered
  7. customevaporated to dryness
  8. customThe residue is crystallized from diethyl ether
  9. custom1.12 g (4.16 mmol)=86.68% of the theoretical yield
  10. customis obtained

출처 및 근거

ORD 기록
ord-7068af3026e04935ba61ca13c7ac8a53
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05130119

연결된 노트

불러오는 중…