Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Fluoro-3-(trifluoromethyl)aniline → 4-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl)benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Fluoro-3-(trifluoromethyl)aniline | HCID 75377 | — |
| 반응물 | 4-(Chlorosulfonyl)benzoic acid | HCID 82385 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 4-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl)benzoic acid | HCID 3699990 | 908.4% |
반응 단계
Analogously to Example 10, 2.21 g (10 mmol) of 4-chlorosulfonyl-benzoic acid is reacted with 1.79 g (10 mmol) of 4-fluoro-3-(trifluoromethyl)-aniline in pyridine and the crude product is crystallized from ethanol. 3.3 g=90.84 mmol of crystalline product is obtained. Melting point 238°-241° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05130119 |
| 출처 데이터셋 | uspto-grants-1992_07 |
| ORD ID | ord-e0350539f1414eb2a75b9ac2d5afcda4 |
| 출처 메모 | uspto-grants-1992_07 |