Hydrogen Bromide → 3-Methylpiperidin-4-one hydrobromide

HRID 654128노트

반응식

HRID 654128 반응식
C([N:5]1[CH2:10][CH2:9][C:8](=[O:11])[C:7](C(OC)=O)([CH3:12])[CH2:6]1)(OC)=O.[BrH:17]>CO>[BrH:17].[CH3:12][CH:7]1[C:8](=[O:11])[CH2:9][CH2:10][NH:5][CH2:6]1

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 3015585Dimethyl 3-methyl-4-oxopiperidine-1,3-dicarboxylate

생성물 1

HCID 200945873-Methylpiperidin-4-one hydrobromide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 1,3-dicarbomethoxy-3-methyl-4-piperidone (51.45 g, 225 mmol) in hydrobromic acid (48%, 250 mL) is heated under reflux for 4 h and then cooled to room temperature. The resultant solution is concentrated in vacuo to give an orange colored solid. The solid is suspended in methanol (50 mL) and concentrated in vacuo again to give 3-methyl-4-piperidone hydrobromide salt: 42.9 g; 98%; mp 203°-205° C.

후처리

  1. temperatureunder reflux for 4 h
  2. concentrationThe resultant solution is concentrated in vacuo
  3. customto give an orange colored solid
  4. concentrationconcentrated in vacuo again

출처 및 근거

ORD 기록
ord-f93e8ecb4d8445cd8f7ec67a6d88decd
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05130321

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