Acetic Anhydride → N-(2,3-Dihydro-1H-inden-2-yl)formamide

HRID 654192노트

반응식

HRID 654192 반응식
C(O[C:5](=[O:7])C)(=O)C.Cl.[NH2:9][CH:10]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11]1.C([O-])(=O)C.[Na+]>C(O)=O>[CH:5]([NH:9][CH:10]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11]1)=[O:7]

참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 1227642-Aminoindan hydrochlorideHCID 517045Sodium Acetate

생성물 1

HCID 14835235N-(2,3-Dihydro-1H-inden-2-yl)formamide

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

Acetic anhydride (40 ml) and formic acid (20 ml) were mixed and heated at 50° for 15 minutes with stirring. 2-Aminoindane hydrochloride (25 g) (see J. Med. Chem., 1980, 23, page 745) and sodium acetate (20 g) were added to this mixture which was then stirred at room temperature for 24 hours. The reaction mixture was poured into ice/water and extracted three times with methylene chloride. The combined organic layers were washed with water and aqueous sodium carbonate, dried (MgSO4) and evaporated in vacuo to give the title compound, yield 17.6 g, m.p. 72°-74°.

후처리

  1. temperatureheated at 50° for 15 minutes
  2. stirringwas then stirred at room temperature for 24 hours
  3. extractionextracted three times with methylene chloride
  4. washThe combined organic layers were washed with water and aqueous sodium carbonate
  5. dry with materialdried (MgSO4)
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-de49f0190f094a02992453fc6eadb9af
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05130334

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