Hydroquinone → N-Octyl-beta-alanine

HRID 65420

반응식

HRID 65420 반응식
[CH2:1]([NH2:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].C1(C=CC(O)=CC=1)O.[C:18]([OH:22])(=[O:21])[CH:19]=[CH2:20].[OH-].[Na+]>CC(C)=O.CO>[CH2:1]([NH:9][CH2:20][CH2:19][C:18]([OH:22])=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

참가 물질

7

반응물 4

HCID 785HydroquinoneHCID 6581Acrylic AcidHCID 8143OctylamineHCID 14798Sodium Hydroxide

생성물 1

HCID 13765821N-Octyl-beta-alanine수율 78%

시약·촉매·용매 2

HCID 180Acetone용매HCID 887Methanol용매

실험 절차

To a mixture of n-octylamine (516 g, 4.0 mols), hydroquinone (200 mg) and methanol (400 ml), acrylic acid (144 g, 2.0 mols) was added dropwise with stirring while cooling with ice. After addition, the mixture was refluxed while heating for 4 hours. After cooled to room temperature, NaOH (80 g, 2.0 mols) was added. The reaction mixture was despersed in 6 liters of acetone, and filtration and drying were carried out to obtain the Na salt of N-n-octyl-β-alanine as white crystals having a melting point (dec.) of 242° C. (349 g Yield: 78%).

후처리

  1. additionwas added dropwise
  2. temperaturewhile cooling with ice
  3. additionAfter addition
  4. temperaturethe mixture was refluxed
  5. temperaturewhile heating for 4 hours
  6. filtrationfiltration
  7. customdrying

출처 및 근거

ORD 기록
ord-5e8802d8235240cab6cb20b4167dd222
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04614699

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