Hydrochloric Acid → 1,3,5-Triazin-2-amine, 4-propoxy-6-(trifluoromethyl)-

HRID 654266

반응식

HRID 654266 반응식
[NH2:1][C:2]1[N:7]=[C:6](C(Cl)(Cl)Cl)[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1.[CH2:16]([O-:19])[CH2:17][CH3:18].[Na+].Cl>C(O)CC>[NH2:1][C:2]1[N:7]=[C:6]([O:19][CH2:16][CH2:17][CH3:18])[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 110114464-(trichloromethyl)-6-(trifluoromethyl)-1,3,5-triazin-2-amineHCID 236693631-Propanol, sodium salt (1:1)2회

생성물 1

HCID 109001931,3,5-Triazin-2-amine, 4-propoxy-6-(trifluoromethyl)-

시약·촉매·용매 1

HCID 10311-Propanol용매2회

반응 조건

온도
75 °C

실험 절차

20.0 g (71 mmol) of 2-amino-4-trichloromethyl-6-trifluoromethyl-1,3,5-triazine were added at 22° C. to a solution of 0.58 g (7.1 mmol) of sodium propanolate in 40 ml of propanol. The resulting yellow mixture was then heated at 75° C. for 30 minutes, after which a further 0.58 g (7.1 mmol) of sodium propanolate in 10 ml of propanol was added and the mixture was heated at 75° C. for 10 minutes. The reaction mixture was cooled to 20° C. and then neutralized with 2 normal aqueous hydrochloric acid. After this, most of the solvent was removed under reduced pressure, and the residue was slowly diluted with 40 ml of water. The solid which formed was separated off, washed with 5 ml of water and dried at 40° C. under reduced pressure.

후처리

  1. temperaturethe mixture was heated at 75° C. for 10 minutes
  2. temperatureThe reaction mixture was cooled to 20° C.
  3. customAfter this, most of the solvent was removed under reduced pressure
  4. additionthe residue was slowly diluted with 40 ml of water
  5. customThe solid which formed
  6. customwas separated off
  7. washwashed with 5 ml of water
  8. customdried at 40° C. under reduced pressure

출처 및 근거

ORD 기록
ord-4b7baf73c2e7414297b71a36cdfe8b58
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05130428

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