Monobasic potassium phosphate → Ribavirin

반응식

[NH:1]1[CH:5]=[N:4][C:3]([C:6]([NH2:8])=[O:7])=[N:2]1.[O:9]=[CH:10][C@@H:11]([C@@H:13]([C@@H:15]([CH2:17][OH:18])[OH:16])[OH:14])O.P([O-])(O)(O)=O.[K+]>>[CH:5]1[N:1]([C@@H:17]2[O:18][C@H:11]([CH2:10][OH:9])[C@@H:13]([OH:14])[C@H:15]2[OH:16])[N:2]=[C:3]([C:6]([NH2:8])=[O:7])[N:4]=1

참가 물질

반응물 3

HCID 516951Monobasic potassium phosphate

HCID 5311110Aldehydo-D-ribose

HCID 178513825HCID 178513825, 화합물

생성물 1

HCID 37542Ribavirin

실험 절차

To each cell suspension was added each 1 ml of an aqueous solution (pH 7.0) containing 20 mM 1,2,4-triazole-3-carboxamide, 20 mM of each of the various ribose donors as shown in Table 3 and 25 mM of monopotassium dihydrogen phosphate, and the reaction was carried out at 60° C. for 24 hours. After completion of the reaction, the cells were removed by centrifugation, and the supernatant was analyzed to obtain the results of ribavirin yield as shown in Table 3.