4,5-dihydro-1H-imidazole-2-sulfonic acid → 2-(trans-2-Ethylcyclohexylamino)-2-imidazoline

HRID 654283

반응식

HRID 654283 반응식
Cl.[CH2:2]([C@@H:4]1[CH2:9][CH2:8][CH2:7][CH2:6][C@H:5]1[NH2:10])[CH3:3].[NH:11]1[CH2:15][CH2:14][N:13]=[C:12]1S(O)(=O)=O>C(O)C(C)C>[CH2:2]([C@@H:4]1[CH2:9][CH2:8][CH2:7][CH2:6][C@H:5]1[NH:10][C:12]1[NH:13][CH2:14][CH2:15][N:11]=1)[CH3:3]

참가 물질

4

반응물 2

HCID 2745614,5-dihydro-1H-imidazole-2-sulfonic acidHCID 12405726trans-2-Ethylcyclohexylamine hydrochloride

생성물 1

HCID 544099042-(trans-2-Ethylcyclohexylamino)-2-imidazoline수율 65%

시약·촉매·용매 1

HCID 6560Isobutanol용매

반응 조건

온도
125 °C

실험 절차

A mixture of trans-2-ethylcyclohexylamine hydrochloride (0.30 g, 2.36 mmol), imidazoline-2-sulfonic acid (0.704 g, 4.72 mmol) and isobutanol (3 ml) was heated to 125° C. and maintained at that temperature for 2 hours. The mixture was cooled to room temperature, concentrated in vacuo and chromatographed (silica gel, 3:1 CHCl3 /CH3OH saturated with NH3 (g)) to yield 0.253 g (a yield of 65%) of the title compound as a white solid, which was characterized spectroscopically.

후처리

  1. temperaturemaintained at that temperature for 2 hours
  2. temperatureThe mixture was cooled to room temperature
  3. concentrationconcentrated in vacuo
  4. customchromatographed (silica gel, 3:1 CHCl3 /CH3OH saturated with NH3 (g))

출처 및 근거

ORD 기록
ord-06633e46418b4ffbbd751cefa9a63344
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05130441

연결된 노트

불러오는 중…