Monobasic potassium phosphate → Ribavirin

HRID 65430

반응식

HRID 65430 반응식
[NH:1]1[CH:5]=[N:4][C:3]([C:6]([NH2:8])=[O:7])=[N:2]1.P([O-])(O)(O)=O.[K+].[O:15]=[CH:16][C@@H:17]([C@@H:19]([C@@H:21]([CH2:23][OH:24])[OH:22])[OH:20])O>>[CH:5]1[N:1]([C@@H:23]2[O:24][C@H:17]([CH2:16][OH:15])[C@@H:19]([OH:20])[C@H:21]2[OH:22])[N:2]=[C:3]([C:6]([NH2:8])=[O:7])[N:4]=1

참가 물질

4

반응물 3

HCID 516951Monobasic potassium phosphateHCID 5311110Aldehydo-D-riboseHCID 178513825HCID 178513825, 화합물

생성물 1

HCID 37542Ribavirin

실험 절차

To each suspension was added each 1 ml of an aqueous solution (pH 7.0) containing 20 mM 1,2,4-triazole-3-carboxamide, 20 ml of various ribose donors as shown in Table 10 and 25 mM monopotassium dihydrogen phosphate, and the reaction was carried out at 60° C. for 20 hours. After the reaction, the microbial cells were removed by centrifugation and the supernatant was analyzed to give the results of ribavirin yields as shown in Table 10.

후처리

  1. customAfter the reaction
  2. customthe microbial cells were removed by centrifugation
  3. customto give the

출처 및 근거

ORD 기록
ord-0e3c0a1ca247400ea7570e83d8abcee8
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04614719

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