Monobasic potassium phosphate → Ribavirin

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[NH:1]1[CH:5]=[N:4][C:3]([C:6]([NH2:8])=[O:7])=[N:2]1.[C@@H:9]1(N2C3N=CN=C(O)C=3N=C2)[O:17][C@H:14]([CH2:15][OH:16])[C@@H:12]([OH:13])[C@H:10]1[OH:11].P([O-])(O)(O)=O.[K+]>>[CH:5]1[N:1]([C@@H:9]2[O:17][C@H:14]([CH2:15][OH:16])[C@@H:12]([OH:13])[C@H:10]2[OH:11])[N:2]=[C:3]([C:6]([NH2:8])=[O:7])[N:4]=1

참가 물질

반응물 3

HCID 516951Monobasic potassium phosphate

HCID 178513825HCID 178513825, 화합물

HCID 178521066(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-hydroxypurin-9-yl)oxolane-3,4-diol

생성물 1

HCID 37542Ribavirin수율 72.55%

실험 절차

The above cell suspension was added to 800 ml of an aqueous solution containing 50 mM 1,2,4-triazole-3-carboxamide, 75 mM inosine and 50 mM monopotassium dihydrogen phosphate, and the reaction was carried out at 60° C. for 24 hours to give a ribavirin yield of 72.55%.

출처 및 근거

ORD 기록: ord-54f80f80ac274c9a93447d460ff98ed6
출처 데이터셋: uspto-grants-1986_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04614719

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