4,4'-Dihydroxybiphenyl → HCID 19887240, 화합물

HRID 654417노트

반응식

HRID 654417 반응식
Br[CH2:2][CH2:3][O:4][CH2:5][CH2:6][CH2:7][CH3:8].[OH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:5]([O:4][CH2:3][CH2:2][O:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)=[CH:14][CH:15]=1)[CH2:6][CH2:7][CH3:8]

참가 물질

5

반응물 3

HCID 71124,4'-DihydroxybiphenylHCID 11430Potassium CarbonateHCID 1387612-Butoxyethyl bromide

생성물 1

HCID 19887240HCID 19887240, 화합물수율 20%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

One gram (5.5 millimoles) of 1-bromo-2-butoxyethane was combined with 5.5 grams (30 millimoles) of 4,4'-dihydroxybiphenyl in 75 mls. of acetonitrile. To the reaction mixture were added 8.3 grams (60 millimoles) of finely ground potassium carbonate. Stirring was begun and the reaction mixture was brought to reflux and maintained for 48 hours. The reaction product was filtered, washed with acetonitrile and evaporated for removal of solvent. The product was passed through a silica gel chromatographic column using dichloromethane eluent, for recovery of 0.25 gram (20% yield) of a biphenol ether compound having the following formula confirmed by TLC, IR and mass spectral analyses: ##STR26##

후처리

  1. temperatureto reflux
  2. temperaturemaintained for 48 hours
  3. filtrationThe reaction product was filtered
  4. washwashed with acetonitrile
  5. customevaporated for removal of solvent

출처 및 근거

ORD 기록
ord-cc03d9841e7b41ffb2eb7a7d00bd189c
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05132041

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