Methyl iodide → 5-Chloro-3-methyl-3-phenyl-1,3-dihydro-2H-indol-2-one

HRID 65448노트

반응식

HRID 65448 반응식
[C:1]1([CH:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([Cl:16])[CH:14]=3)[NH:9][C:8]2=[O:17])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:18](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O.O>[CH3:18][C:7]1([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([Cl:16])[CH:14]=2)[NH:9][C:8]1=[O:17]

참가 물질

6

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 190764863-Phenyl-5-chlorooxindole

생성물 1

HCID 202330995-Chloro-3-methyl-3-phenyl-1,3-dihydro-2H-indol-2-one

시약·촉매·용매 2

HCID 180Acetone용매HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

10 g of 3-phenyl-5-chlorooxindole were dissolved in 100 ml of acetone and 20 ml of water, 2.9 g of potassium carbonate and 2.9 ml of methyl iodide were added and the mixture was warmed at 50° C. for 3 hours and concentrated; water was added to the residue, which was extracted with ethyl acetate, and the extract was dried over magnesium sulfate, and the solvent was removed. The residue was recrystallized from ethanol. Melting point 180°-181° C.

후처리

  1. concentrationconcentrated
  2. additionwater was added to the residue, which
  3. extractionwas extracted with ethyl acetate
  4. dry with materialthe extract was dried over magnesium sulfate
  5. customthe solvent was removed
  6. customThe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-360c2f98109549b791910c86c16f8403
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04614739

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