참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Thiophenecarboxaldehyde | HCID 7364 | — |
| 반응물 | Isopropyl chloroacetate | HCID 7759 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 85316399 | HCID 85316399 | — |
반응 단계
A mixture of 168 g of 2-thienylcarboxaldehyde and 12.9 g of isopropyl chloroacetate is then introduced over 30 minutes. The solution is stirred for 25 minutes at this temperature and 257 g of an aqueous solution of sodium hydroxide at a concentration of 35% are then added over 30 minutes. The mixture is stirred at 50° C. for 2 hours, is cooled to 25° C. and 161.5 g of hydroxylamine hydrochloride dissolved in 200 ml of water are then introduced over 30 minutes. The mixture is kept stirred for 30 minutes and is then added to 1.5 l of water and 1.5 l of dichloromethane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05132435 |
|---|
| 출처 데이터셋 | uspto-grants-1992_07 |
|---|
| ORD ID | ord-2757e7a18a954c8396c2cb67dba87d3d |
|---|
| 출처 메모 | uspto-grants-1992_07 |
|---|
