反应详情

温度

50 °C

A mixture of 168 g of 2-thienylcarboxaldehyde and 12.9 g of isopropyl chloroacetate is then introduced over 30 minutes. The solution is stirred for 25 minutes at this temperature and 257 g of an aqueous solution of sodium hydroxide at a concentration of 35% are then added over 30 minutes. The mixture is stirred at 50° C. for 2 hours, is cooled to 25° C. and 161.5 g of hydroxylamine hydrochloride dissolved in 200 ml of water are then introduced over 30 minutes. The mixture is kept stirred for 30 minutes and is then added to 1.5 l of water and 1.5 l of dichloromethane.

1. additionis then introduced over 30 minutes
2. additionare then added over 30 minutes
3. temperatureis cooled to 25° C.
4. additionare then introduced over 30 minutes
5. stirringThe mixture is kept stirred for 30 minutes