Bromotrichloromethane → Ethyl 2-acetyl-2-bromobutyrate

HRID 654610

반응식

[C:1]([CH:4]([CH2:10][CH3:11])[C:5]([O:7][CH2:8][CH3:9])=[O:6])(=[O:3])[CH3:2].[Br:12]C(Cl)(Cl)Cl.O.O.O.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>>[C:1]([C:4]([Br:12])([CH2:10][CH3:11])[C:5]([O:7][CH2:8][CH3:9])=[O:6])(=[O:3])[CH3:2]

참가 물질

반응물 3

HCID 6383Bromotrichloromethane

HCID 79065Butanoic acid, 2-ethyl-3-oxo-, ethyl ester

HCID 11726816Tetrabutylammonium Fluoride Trihydrate

생성물 1

HCID 11009975Ethyl 2-acetyl-2-bromobutyrate수율 56.5%

실험 절차

In a 10 mL round-bottom flask, 1.58 g of ethyl 2-acetylbutyrate (10 mmol), 2.1 g bromotrichloromethane (10.5 mmol), and 200 mg of tetra-n-butylammonium fluoride trihydrate (0.632 mmol) were mixed at 24° C. for 1 h. Gas chromatographic analysis of the resulting mixture showed the presence of 1.34 g of ethyl 2-acetyl-2-bromobutyrate (56% yield).

출처 및 근거

ORD 기록: ord-402593d179124bc695f6000a2107b035
출처 데이터셋: uspto-grants-1992_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05132475

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