Oxalic Acid → HCID 19886321, 화합물

HRID 654739

반응식

HRID 654739 반응식
[CH2:1]1[CH:5]2[CH:6]([C:8]3[O:12][N:11]=[C:10]([NH2:13])[N:9]=3)[CH2:7][N:3](C2)[CH2:2]1.F[C:15](F)(F)[C:16](O)=O.[CH3:21][CH:22](O)[CH3:23].[O:25]=[C:26]([C:28](=[O:30])[OH:29])[OH:27]>ClCCl.ClCCl.CO>[C:28]([OH:30])(=[O:29])[C:26]([OH:27])=[O:25].[CH2:21]([N:13]([CH2:26][C:15]#[CH:16])[C:10]1[N:9]=[C:8]([C:6]2[CH2:7][NH:3][CH2:2][CH2:1][CH:5]=2)[O:12][N:11]=1)[C:22]#[CH:23]

참가 물질

7

반응물 4

HCID 971Oxalic AcidHCID 3776IsopropanolHCID 6422Trifluoroacetic acidHCID 1639383-(3-Amino-1,2,4-oxadiazol-5-yl)-1-azabicyclo(2.2.1)heptane

생성물 1

HCID 19886321HCID 19886321, 화합물

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 21226129Dichloromethane methanol용매

실험 절차

The foregoing oxadiazole (135 mg, 0.00039 mol) was stirred with trifluoroacetic acid (0.18 mL, 0.0024 mol) in dichloromethane (6 mL) for 24 hours. The hydrogen oxalate salt had mp 134°-135° C. (propan-2-ol). Rf=0.78 in dichloromethane/methanol (9:1) on alumina plates. Mass Spectrum, m/z 242 for M+ of free base. (Found: C, 53.87; H, 4.90; N, 16.52. C13H14N4O. C2H2O4 requires C, 54.21; H, 4.85; N, 16.86%).

출처 및 근거

ORD 기록
ord-b3091bf1d1f0497e859f22f0ae4c5e0e
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05134146

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