Water → (2,3-Dihydro-1-benzofuran-2-yl)methanol

HRID 654752

반응식

HRID 654752 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[O:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[CH2:9][CH:8]1[C:16](O)=[O:17].O.[OH-].[Na+]>C(OCC)C>[O:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[CH2:9][CH:8]1[CH2:16][OH:17]

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 27765552,3-Dihydro-1-benzofuran-2-carboxylic acidHCID 21226445Aluminium lithium hydride

생성물 1

HCID 2795428(2,3-Dihydro-1-benzofuran-2-yl)methanol수율 90%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A three-necked flask is charged with 17 g of lithium aluminum hydride dissolved in anhydrous ethyl ether. 3 g of 2,3-dihydro-2-benzofurancarboxylic acid (Chim. Ler., (1973), 3, p. 259), dissolved in 1,140 ml of ethyl ether, are then introduced. The reaction medium is left stirring overnight. It is then hydrolyzed in an ice bath with 15.2 ml of water, 15.2 ml of 4N sodium hydroxide and then 45.2 ml of water. The complex is drained and washed with ethyl ether and the filtrate is dried and distilled to obtain the expected compound

후처리

  1. additionare then introduced
  2. waitThe reaction medium is left
  3. washwashed with ethyl ether
  4. customthe filtrate is dried
  5. distillationdistilled

출처 및 근거

ORD 기록
ord-e7dd00e04394442096bec33f41038b65
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05134147

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