Water → 2-Chloromethylbenzofuran

HRID 654757

반응식

HRID 654757 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[CH2:10]O.S(Cl)([Cl:14])=O.O>C(Cl)(Cl)Cl.ClCCl>[Cl:14][CH2:10][C:2]1[O:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=1

참가 물질

6

반응물 3

HCID 962WaterHCID 24386Thionyl ChlorideHCID 27762631-Benzofuran-2-Ylmethanol

생성물 1

HCID 1843482-Chloromethylbenzofuran수율 80%

시약·촉매·용매 2

HCID 6212Chloroform용매HCID 6344Dichloromethane용매

실험 절차

A three-necked flask is charged with 33.2 g of 2-benzofuranylmethanol dissolved in 450 ml of anhydrous chloroform, 48.8 ml of thionyl chloride are then introduced dropwise and the temperature is raised gently to reflux and maintained for 3 hours 30 minutes. The reaction medium is then cooled and poured into 1 1 of water, and is thereafter diluted with 500 ml of dichloromethane. After settling has taken place, the organic phase is washed to neutrality and dried over anhydrous magnesium sulfate, the solvent is evaporated off and the residue is distilled under vacuum to obtain the expected compound.

후처리

  1. temperaturethe temperature is raised gently
  2. temperatureto reflux
  3. temperaturemaintained for 3 hours 30 minutes
  4. temperatureThe reaction medium is then cooled
  5. washthe organic phase is washed to neutrality
  6. dry with materialdried over anhydrous magnesium sulfate
  7. customthe solvent is evaporated off
  8. distillationthe residue is distilled under vacuum

출처 및 근거

ORD 기록
ord-48ea5c07afb64da1b9107fd6cb17100b
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05134147

연결된 노트

불러오는 중…