Sodium Hydroxide → (S)-3-benzyloxymethyloxy-2-methylpropionic acid

HRID 654991노트

반응식

HRID 654991 반응식
[CH2:1]([O:8][CH2:9][O:10][CH2:11][C@H:12]([CH3:17])[C:13]([O:15]C)=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO.O>[CH2:1]([O:8][CH2:9][O:10][CH2:11][C@H:12]([CH3:17])[C:13]([OH:15])=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 14348497methyl (S)-3-benzyloxymethyloxy-2-methylpropionate

생성물 1

HCID 14348499(S)-3-benzyloxymethyloxy-2-methylpropionic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Methyl (S)-3-benzyloxymethyloxy-2-methylpropionate (1.20 g; 5 mmole) was dissolved in methanol (12 ml), and a lN sodium hydroxide solution (5.5 ml) was added thereto with ice-cooling, followed by stirring at room temperature for overnight. The reaction mixture was diluted with water (30 ml) and washed with ether (20 ml) two times. The aqueous layer was acidified with 6N hydrochloric acid with ice-cooling and extracted with ethyl acetate (30 ml) three times. The extracts were combined together, washed with water and dried over anhydrous sodium sulfate and concentrated under reduced pressure to give (S)-3-benzyloxymethyloxy-2-methylpropionic acid.

후처리

  1. temperaturewith ice-cooling
  2. washwashed with ether (20 ml) two times
  3. temperaturecooling
  4. extractionextracted with ethyl acetate (30 ml) three times
  5. washwashed with water
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ffeef2f695554ddfb9bdfc29635e1d2d
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05134231

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