Acetic Acid → HCID 57742362, 화합물

HRID 655303노트

반응식

HRID 655303 반응식
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([CH2:12][C:13]1[N:14]([NH2:19])[C:15]([NH2:18])=[N:16][N:17]=1)=[CH:7][CH:6]=2.[CH:20]([CH:22]=O)=O.C(O)(=O)C>O>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([CH2:12][C:13]1[N:14]3[N:19]=[CH:20][CH:22]=[N:18][C:15]3=[N:16][N:17]=1)=[CH:7][CH:6]=2

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 7860GlyoxalHCID 57742338HCID 57742338, 화합물

생성물 1

HCID 57742362HCID 57742362, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 5-(3-bromo-quinolin-6-ylmethyl)-[1,2,4]triazole-3,4-diamine (977 mg, 3 mmol), glyoxal (40% solution in water, 5 mL), acetic acid (10 mL) and water (2 mL) was stirred at ambient temperature for 18 hours. After such time the mixture was filtered and the filtrate was concentrated onto silica gel and via flash column chromatography (SiO2 12 g, dichloromethane/CH3OH, 0-10%) to return the title compound a white solid (298 mg, 29%). Analytical data presented in Table 1.

후처리

  1. filtrationAfter such time the mixture was filtered
  2. concentrationthe filtrate was concentrated onto silica gel and via flash column chromatography (SiO2 12 g, dichloromethane/CH3OH, 0-10%)

출처 및 근거

ORD 기록
ord-a46a1aac0b64403fa16bdb875cc8fcba
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071581B2

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