Thionyl Chloride → 4-(2-Chloroethyl)-1,2-dimethoxybenzene

HRID 655597

반응식

HRID 655597 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12]O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].S(Cl)([Cl:16])=O>C(Cl)(Cl)Cl>[Cl:16][CH2:12][CH2:11][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 819113,4-Dimethoxyphenethyl alcohol

생성물 1

HCID 30153594-(2-Chloroethyl)-1,2-dimethoxybenzene

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

The reaction mixture of 2-(3,4-dimethoxyphenyl)ethanol (6.0 g, 32.8 mmol) and thionyl chloride (19 g, 164 mmol) in chloroform (20 mL) was stirred at reflux for 4 h, concentrated, and partitioned between water and ethyl acetate. The organic layer was washed with NaHCO3 and brine, dried over anhydrous sodium sulfate, and concentrated to afford 4-(2-chloroethyl)-1,2-dimethoxybenzene (K) quantitatively (6.6 g).

후처리

  1. temperatureat reflux for 4 h
  2. concentrationconcentrated
  3. custompartitioned between water and ethyl acetate
  4. washThe organic layer was washed with NaHCO3 and brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-9fe038c086794b04aa89d880c5f58bba
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071602B2

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