Hydrochloric Acid → 1-(1-Benzothiophen-4-yl)piperazine hydrochloride

HRID 655635노트

반응식

HRID 655635 반응식
[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:8][CH:9]=[CH:10][C:3]1=2>CO>[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:8][CH:9]=[CH:10][C:3]1=2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 210731871-(Benzo[b]thiophen-4-yl)piperazine

생성물 1

HCID 574825411-(1-Benzothiophen-4-yl)piperazine hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Then, 3.7 ml of concentrated hydrochloric acid was added to a methanol solution of 9.5 g of 1-benzo[b]thiophen-4-yl-piperazine, and the solvent was evaporated under reduced pressure. Ethyl acetate was added to the obtained residue and precipitated crystals were obtained by filtration. Recrystallization was performed from methanol to obtain 1-benzo[b]thiophen-4-yl-piperazine hydrochloride as colorless needle-like crystals.

후처리

  1. customthe solvent was evaporated under reduced pressure
  2. additionEthyl acetate was added to the obtained residue
  3. customprecipitated crystals
  4. customwere obtained by filtration
  5. customRecrystallization

출처 및 근거

ORD 기록
ord-b46f908a3ccb4f26adb9e601a1172dab
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071600B2

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