2-(1-hydroxyethyl)pyrimidin-4(3H)-one → 2-Acetylpyrimidin-4(1H)-one

HRID 655780노트

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HRID 655780 반응식
[OH:1][CH:2]([C:4]1[NH:9][C:8](=[O:10])[CH:7]=[CH:6][N:5]=1)[CH3:3]>ClC(Cl)C.[O-2].[O-2].[Mn+4]>[C:2]([C:4]1[NH:9][C:8](=[O:10])[CH:7]=[CH:6][N:5]=1)(=[O:1])[CH3:3]

참가 물질

4

반응물 1

HCID 110189492-(1-hydroxyethyl)pyrimidin-4(3H)-one2회

생성물 1

HCID 221217222-Acetylpyrimidin-4(1H)-one수율 32.6%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 63651,1-Dichloroethane용매

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온도
90 °C

실험 절차

To a stirred solution of 2-(1-hydroxyethyl)pyrimidin-4(3H)-one (Intermediate 50, 5 g, 35.71 mmol) in dichloroethane (200 mL), manganese dioxide (31 g, 357.1 mmol) was added. The reaction mixture was heated to 90° C. for 5 h. The reaction mixture was filtered through a celite bed and washed with dichloroethane (60 mL). The filtrate was concentrated to dryness to yield 1.6 g (32.6%) 2-acetylpyrimidin-4(3H)-one.

후처리

  1. filtrationThe reaction mixture was filtered through a celite bed
  2. washwashed with dichloroethane (60 mL)
  3. concentrationThe filtrate was concentrated to dryness

출처 및 근거

ORD 기록
ord-ecb4cbdcff4140c6b39aa007195949d3
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071605B2

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