Hydrochloric Acid → (4-Pyrazol-1-yl-phenyl)-hydrazine Hydrochloride

HRID 655866노트

반응식

HRID 655866 반응식
C(OC([N:8]([C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH:20]=[CH:19][CH:18]=[N:17]2)=[CH:12][CH:11]=1)[NH2:9])=O)(C)(C)C.O1CCOCC1.[ClH:27]>C(Cl)Cl>[ClH:27].[N:16]1([C:13]2[CH:14]=[CH:15][C:10]([NH:8][NH2:9])=[CH:11][CH:12]=2)[CH:20]=[CH:19][CH:18]=[N:17]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 68820898N-(4-Pyrazol-1-yl-phenyl)-hydrazinecarboxylic Acid tert-butyl Ester

생성물 1

HCID 68824303(4-Pyrazol-1-yl-phenyl)-hydrazine Hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Title compound 51A, N-(4-Pyrazol-1-yl-phenyl)-hydrazinecarboxylic acid tert-butyl ester (0.42 g, 1.0 eq, 1.53 mmol) was suspended in a mixture of 4M HCl in Dioxane (6.5 ml, 17.0 eq, 26 mmol) and DCM (5 ml). The mixture was then stirred at room temperature for 24 hours solvent was then removed in vacuo to yield impure title compound. (0.31 g). LCMS: [M+H]+=158/175, 65% purity.

후처리

  1. customwas then removed in vacuo

출처 및 근거

ORD 기록
ord-2f4bf8455d0a404b990f424296af13c9
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071607B2

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