Hydrochloric Acid → HCID 70166468, 화합물

HRID 65594노트

반응식

HRID 65594 반응식
[CH3:1][O:2][C:3](=[O:30])[C@H:4]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[NH:5][C:6](=[O:21])[C@H:7]([CH2:19][OH:20])[NH:8]C(OCC1C=CC=CC=1)=O.[ClH:31].[H][H]>CO>[ClH:31].[CH3:1][O:2][C:3](=[O:30])[C@H:4]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[NH:5][C:6](=[O:21])[C@H:7]([CH2:19][OH:20])[NH2:8]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 13190522Z-Ser-Tyr-OMeHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 70166468HCID 70166468, 화합물

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a mixture consisting of 4.16 g. of N-benzyloxycarbonyl-L-seryl-L-tyrosine methyl ester [for the preparation of this compound see J. Am. Chem. Soc., 76, 5076 (1954)], 30 ml. of methanol, and 416 mg. of 5% palladium-on-barium sulfate is added 8.7 ml. of methanol containing 400 mg. of hydrogen chloride, and hydrogen is passed over the stirred mixture for 75 minutes. The mixture is then filtered to remove the catalyst, and the filtrate is evaporated to dryness under reduced pressure to give a solid residue of L-seryl-L-tyrosine methyl ester hydrochloride, which is suitable for use without further purification.

후처리

  1. filtrationThe mixture is then filtered
  2. customto remove the catalyst
  3. customthe filtrate is evaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-a43679a8b75349c3aad8097a4b646581
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04128540

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