Sodium Hydroxide → HCID 66918073, 화합물

HRID 655941노트

반응식

HRID 655941 반응식
[Cl:1][C:2]1[C:3]([CH:9]2[CH2:11][CH:10]2[C:12]([O:14]CC)=[O:13])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[C:3]([CH:9]2[CH2:11][CH:10]2[C:12]([OH:14])=[O:13])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 66918072Ethyl 2-(3,5-dichloropyridin-2-yl)cyclopropanecarboxylate

생성물 1

HCID 66918073HCID 66918073, 화합물수율 91.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1.65 g of ethyl 2-(3,5-dichloropyridin-2-yl)cyclopropanecarboxylate (0.00634 mol) are dissolved in 20 ml of ethanol, 9.5 ml of sodium hydroxide 1M are added to the reaction mixture which is refluxed for 4 hours and left at room temperature overnight. After concentration in vacuo, 30 ml of water are added to the reaction mixture which is extracted twice with ethyl acetate (20 ml). The aqueous phase is acidified with HCl 1M. The precipate which forms is filtered, air-dried to yield to 1.35 g of 2-(3,5-dichloropyridin-2-yl)cyclopropanecarboxylic acid (87%).

후처리

  1. temperatureis refluxed for 4 hours
  2. concentrationAfter concentration in vacuo, 30 ml of water
  3. additionare added to the reaction mixture which
  4. extractionis extracted twice with ethyl acetate (20 ml)
  5. filtrationThe precipate which forms is filtered
  6. customair-dried

출처 및 근거

ORD 기록
ord-b190fc5f0f9644e195ce4514c4cc841c
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071629B2

반응 노트

불러오는 중…