Dichloromethane → Methyl 5-bromoindoline-7-carboxylate
반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:10]=1)[N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5]2.ClCCl.[OH-].[Na+]>FC(F)(F)C(O)=O>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:10]=1)[NH:7][CH2:6][CH2:5]2참가 물질
5
실험 절차
1-(1,1-dimethylethyl) 7-methyl 5-bromo-2,3-dihydro-1H-indole-1,7-dicarboxylate (9 g, 25 mmol) was dissolved in trifluoroacetic acid (6 mL) and stirred at room temperature for 16 hours. Dichloromethane and sodium hydroxide solution (2 M) were added and the organic layer washed twice with sodium hydroxide solution until the aqueous layer pH>7. The organic layer was then concentrated in vacuo to give 6.5 g (100%) of the title compound as a brown solid.
후처리
- washthe organic layer washed twice with sodium hydroxide solution until the aqueous layer pH>7
- concentrationThe organic layer was then concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-099ff6aa91e24915995443e388cabac1
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08071584B2
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