Azetidine → 1-[(5-Bromo-2-thienyl)methyl]azetidine

HRID 656143노트

반응식

HRID 656143 반응식
[Br:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[CH2:12][CH2:11][CH2:10]C2)=[CH:4][CH:3]=1.N1CCC1>>[Br:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[CH2:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 10422AzetidineHCID 593327581-[(5-Bromo-2-thienyl)methyl]pyrrolidine

생성물 1

HCID 593327501-[(5-Bromo-2-thienyl)methyl]azetidine

실험 절차

The above procedure to make 1-[(5-bromo-2-thienyl)methyl]pyrrolidine was repeated except using azetidine (86 mg, 1.5 mmol) as the amine. Following the purification with the SCX column as described -[(5-bromo-2-thienyl)methyl]pyrrolidine an additional purification step on a 40 g ISCO silica column was necessary to afford the title compound (166 mg) of acceptable purity for use in the next reaction.

후처리

  1. customthe purification with the SCX column
  2. customan additional purification step on a 40 g ISCO silica column

출처 및 근거

ORD 기록
ord-694a762037994be086c38cf13e634772
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071584B2

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