4-Amino-2,5-difluorobenzonitrile → 4-(Aminomethyl)-2,5-difluoroaniline
반응식
[NH2:1][C:2]1[C:9]([F:10])=[CH:8][C:5]([C:6]#[N:7])=[C:4]([F:11])[CH:3]=1>[Ni].CO>[NH2:1][C:2]1[C:9]([F:10])=[CH:8][C:5]([CH2:6][NH2:7])=[C:4]([F:11])[CH:3]=1참가 물질
4
실험 절차
4-amino-2,5-difluorobenzonitrile (400 mg) and Raney nickel Catalyst were added to methanol (20 ml) and the mixture was stirred under hydrogen atmosphere at room temperature for 18 hours. After confirming the completion of the reaction, the resulting mixture was filtered through celite and the filtrate was concentrated under reduced pressure. The following procedure was carried out, using the concentrate which was not purified.
후처리
- customthe completion of the reaction
- filtrationthe resulting mixture was filtered through celite
- concentrationthe filtrate was concentrated under reduced pressure
- concentrationconcentrate which
- customwas not purified
출처 및 근거
- ORD 기록
- ord-741b233ad0c846098ea527fb4bc75a45
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08071650B2
반응 노트
불러오는 중…