Hydrochloric Acid → N-(2-Fluoro-4-iodophenyl)methanesulfonamide

HRID 656266

반응식

HRID 656266 반응식
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH2:9].N1C=CC=CC=1.[CH3:16][S:17](Cl)(=[O:19])=[O:18].Cl>ClCCl>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][S:17]([CH3:16])(=[O:19])=[O:18]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 31297Methanesulfonyl chlorideHCID 1856942-Fluoro-4-iodoaniline

생성물 1

HCID 19785608N-(2-Fluoro-4-iodophenyl)methanesulfonamide수율 95%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-fluoro-4-iodophenylamine (1.50 g) was dissolved in dichloromethane (40 ml) and to the solution were added pyridine (1.02 ml) and methanesulfonylchloride (700 μl). The mixture was stirred at room temperature for 1 hour and 1.5 N aqueous hydrochloric acid was added thereto to quench the reaction. The resulting mixture was extracted with dichloromethane, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The obtained residue was column-chromatographed (ethyl acetate/hexane=1/1) to yield the compound 3-2 (1.89 g, 95%).

후처리

  1. customto quench
  2. customthe reaction
  3. extractionThe resulting mixture was extracted with dichloromethane
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customThe obtained residue was column-chromatographed (ethyl acetate/hexane=1/1)

출처 및 근거

ORD 기록
ord-e456631fb3dd416e8419fec0356e2fa2
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071650B2

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