(1-methyl-1H-pyrrol-2-yl)methanamine → 1-(4-t-butylbenzyl)-3-(1-methyl-1H-pyrrol-2-yl)methylthiourea

HRID 656288

반응식

HRID 656288 반응식
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][NH2:8].[C:9]([C:13]1[CH:22]=[CH:21][C:16]([CH2:17][N:18]=[C:19]=[S:20])=[CH:15][CH:14]=1)([CH3:12])([CH3:11])[CH3:10]>C(OCC)(=O)C>[C:9]([C:13]1[CH:22]=[CH:21][C:16]([CH2:17][NH:18][C:19]([NH:8][CH2:7][C:3]2[N:2]([CH3:1])[CH:6]=[CH:5][CH:4]=2)=[S:20])=[CH:15][CH:14]=1)([CH3:12])([CH3:10])[CH3:11]

참가 물질

4

반응물 2

HCID 2776207(1-methyl-1H-pyrrol-2-yl)methanamineHCID 148010411-Tert-butyl-4-(isothiocyanatomethyl)benzene

생성물 1

HCID 590880651-(4-t-butylbenzyl)-3-(1-methyl-1H-pyrrol-2-yl)methylthiourea수율 75.9%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

(1-methyl-1H-pyrrol-2-yl)methylamine (65 mg) and 4-t-butylbenzylisothiocyanate (120 mg) were dissolved in ethyl acetate (30 ml) and the solution was stirred for 12 hours. After the completion of the reaction, the resulting mixture was purified by column-chromatography (ethyl acetate/hexane=1/3) to yield the compound 17-2 (140 mg, 75%)

후처리

  1. customAfter the completion of the reaction
  2. customthe resulting mixture was purified by column-chromatography (ethyl acetate/hexane=1/3)

출처 및 근거

ORD 기록
ord-ad0f65674d824e39a75806ea578f636e
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071650B2

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