Phenethyl Isothiocyanate → 1-(1-methyl-1H-pyrrol-2-ylmethyl)-3-phenethylthiourea

HRID 656289

반응식

HRID 656289 반응식
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][NH2:8].[N:9]([CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[C:10]=[S:11]>C(OCC)(=O)C>[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][NH:8][C:10]([NH:9][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[S:11]

참가 물질

4

반응물 2

HCID 16741Phenethyl IsothiocyanateHCID 2776207(1-methyl-1H-pyrrol-2-yl)methanamine

생성물 1

HCID 590880071-(1-methyl-1H-pyrrol-2-ylmethyl)-3-phenethylthiourea수율 60.1%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

(1-methyl-1H-pyrrol-2-yl)methylamine (65 mg) and (2-isothiocyanatoethyl)benzene (100 mg) were dissolved in ethyl acetate (20 ml) and the solution was stirred for 12 hours. After the completion of the reaction, the resulting mixture was purified by column-chromatography (ethyl acetate/hexane=1/3) to yield the compound 17-3 (97 mg, 60%) as a brown liquid.

후처리

  1. customAfter the completion of the reaction
  2. customthe resulting mixture was purified by column-chromatography (ethyl acetate/hexane=1/3)

출처 및 근거

ORD 기록
ord-60190a4c30bd418ea67d301a066e7155
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071650B2

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