Hydrochloric Acid → HCID 68575364, 화합물

HRID 656463노트

반응식

HRID 656463 반응식
C([N:8]1[CH:13]([C:14]#[N:15])[CH2:12][CH2:11][CH2:10][C:9]1([CH2:18][C:19]([O:21]C(C)(C)C)=[O:20])[C:16]#[N:17])C1C=CC=CC=1.[ClH:26].[H][H]>CO.[Pd]>[ClH:26].[NH2:17][CH2:16][C:9]1([CH2:18][C:19]([OH:21])=[O:20])[CH2:10][CH2:11][CH2:12][CH:13]([CH2:14][NH2:15])[NH:8]1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 86629994HCID 86629994, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 68575364HCID 68575364, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 6.00 mmol of tert-butyl (1-benzyl-2,6-dicyanopiperidin-2-yl)acetate in 40 ml of methanol is admixed with 2 ml of 37% strength aqueous hydrochloric acid and 0.600 g of 10% Pd/C. The reaction mixture is hydrogenated with 4 bar of hydrogen at 22° C. for 18 hours. The reaction mixture is filtered over Hyflo and the filtrate is evaporated. From the residue the crude title compound is identified on the basis of the Rf value. The title compound is used without further purification in the next stage.

후처리

  1. filtrationThe reaction mixture is filtered over Hyflo
  2. customthe filtrate is evaporated
  3. customThe title compound is used without further purification in the next stage

출처 및 근거

ORD 기록
ord-e836a627a44e4f1a816e2b1e751d1ee8
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071773B2

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