(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester → (3-Hydroxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester

HRID 656762

반응식

HRID 656762 반응식
[CH2:1]([O:3][C:4](=[O:24])[CH2:5][C:6]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[C:8]([O:16]CC2C=CC=CC=2)[CH:7]=1)[CH3:2]>CCO>[CH2:1]([O:3][C:4](=[O:24])[CH2:5][C:6]1[CH:11]=[C:10]([C:12]([F:14])([F:13])[F:15])[CH:9]=[C:8]([OH:16])[CH:7]=1)[CH3:2]

참가 물질

3

반응물 1

HCID 58148866(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester

생성물 1

HCID 58149158(3-Hydroxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
50 °C

실험 절차

(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester (1.7 g, 5.6 mmol) was dissolved in EtOH (30 mL) and degassed with N2. 5% Palladium on carbon (1 g) was added, and the reaction was purged with H2 and then stirred under an H2 balloon at 50° C. overnight. The mixture was filtered and concentrated to give (3-Hydroxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester.

후처리

  1. customdegassed with N2
  2. addition5% Palladium on carbon (1 g) was added
  3. customthe reaction was purged with H2
  4. filtrationThe mixture was filtered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e990c05683784aceb3b36a02f1708b5c
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071807B2

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