Sodium Hydroxide → Furo[2,3-c]pyridin-5-ylmethanol

HRID 656967노트

반응식

HRID 656967 반응식
C([O:4][CH2:5][C:6]1[CH:7]=[C:8]2[CH:14]=[CH:13][O:12][C:9]2=[CH:10][N:11]=1)(=O)C.[OH-].[Na+]>O1CCOCC1.O>[O:12]1[C:9]2=[CH:10][N:11]=[C:6]([CH2:5][OH:4])[CH:7]=[C:8]2[CH:14]=[CH:13]1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 22047292HCID 22047292, 화합물

생성물 1

HCID 22047174Furo[2,3-c]pyridin-5-ylmethanol수율 70.2%

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

A solution of furo[2,3-c]pyridin-5-ylmethyl acetate (1.15 g) in 1,4-dioxane (30 ml) and water (10 ml) was treated with 2M sodium hydroxide (12 ml) then stirred at ambient temperature for 18 h. The mixture was then partitioned between ethyl acetate and water. The organic fractions were separated and dried then evaporated to dryness. This gave an oil (0.63 g, 70%).

후처리

  1. customThe mixture was then partitioned between ethyl acetate and water
  2. customThe organic fractions were separated
  3. customdried
  4. customthen evaporated to dryness

출처 및 근거

ORD 기록
ord-dd3c8144f9af4fc7a42c9df27d594f6a
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071592B2

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