Piperonyl alcohol → 1,3-Benzodioxole, 5-(chloromethyl)-

반응식

S(Cl)([Cl:3])=O.[CH2:5]1[O:15][C:14]2[CH:13]=[CH:12][C:9]([CH2:10]O)=[CH:8][C:7]=2[O:6]1>>[CH2:5]1[O:15][C:14]2[CH:13]=[CH:12][C:9]([CH2:10][Cl:3])=[CH:8][C:7]=2[O:6]1

참가 물질

반응물 2

HCID 10322Piperonyl alcohol

HCID 24386Thionyl Chloride

생성물 1

HCID 887131,3-Benzodioxole, 5-(chloromethyl)-

실험 절차

153.9 g (1.29 mols) of thionyl chloride are poured onto 65.6 g (0.431 mol) of 3,4-methylenedioxybenzyl alcohol. The mixture is stirred for 90 minutes at ambient temperature (15°-25° C.) and the excess thionyl chloride is then evaporated. The residue is taken up in dimethylformainde (DMF) and the latter is then evaporated. Finally, the residue is taken up in 500 ml of DMF (it is not necessary to isolate the 3,4-methylenedioxybenzyl chloride thus obtained).

후처리

customthe excess thionyl chloride is then evaporated
customthe latter is then evaporated

출처 및 근거

ORD 기록: ord-6894a54152924af49879deb8373082ee
출처 데이터셋: uspto-grants-1978_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04128656

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