Hydrochloric Acid → N,3,5-tritert-butyl-4-hydroxybenzamide

HRID 65723

반응식

HRID 65723 반응식
[C:1]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([C:15]([CH3:18])([CH3:17])[CH3:16])[C:13]=1[OH:14])[C:8](Cl)=[O:9])([CH3:4])([CH3:3])[CH3:2].ClCCl.[C:22]([NH2:26])([CH3:25])([CH3:24])[CH3:23].Cl>C1C=CC=CC=1.CCCCCC>[C:1]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([C:15]([CH3:18])([CH3:17])[CH3:16])[C:13]=1[OH:14])[C:8]([NH:26][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:9])([CH3:4])([CH3:3])[CH3:2]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 6385Tert-ButylamineHCID 37871873,5-Di-tert-butyl-4-hydroxybenzoyl chloride

생성물 1

HCID 1203452N,3,5-tritert-butyl-4-hydroxybenzamide

시약·촉매·용매 1

HCID 110624Benzene hexane용매

실험 절차

To a stirred solution of 13.43 g. (0.05 mole) of 3,5-di(t-butyl)-4-hydroxybenzoyl chloride in 50 ml. of dichloromethane is added dropwise 8.77 g. (0.12 mole) of t-butylamine. The mixture obtained is neutralized carefully with 10 percent hydrochloric acid and washed thrice with 200 ml. portions of water. The organic layer is dried, then evaporated under vacuum to provide a white residue. The residue is dissolved in hot benzene-hexane mixture and crystallized to provide 3,5-di(t-butyl)-4-hydroxy-N-t-butylbenzamide, m.p. 207°-208° C.

후처리

  1. customThe mixture obtained
  2. washwashed thrice with 200 ml
  3. customThe organic layer is dried
  4. customevaporated under vacuum
  5. customto provide a white residue
  6. customcrystallized

출처 및 근거

ORD 기록
ord-523687a5a331470bbda2d360c890f3dd
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04128664

연결된 노트

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