Phenacyl bromide → alpha-(4-Chloro-2-naphthoxy)acetophenone

HRID 65728

반응식

HRID 65728 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](O)=[CH:4][CH:3]=1.Br[CH2:14][C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:16].C(=O)([O-])[O-:24].[K+].[K+]>C1C=CC=CC=1>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([O:24][CH2:14][C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:16])[CH:3]=1

참가 물질

5

반응물 3

HCID 6259Phenacyl bromideHCID 11430Potassium CarbonateHCID 117874-Chloro-1-naphthol

생성물 1

HCID 20563338alpha-(4-Chloro-2-naphthoxy)acetophenone

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

The product of step A is reacted with α-bromoacetophenone in benzene in the presence of potassium carbonate using the method of Example 1, step A, to provide white crystals of α-(4-chloro-2-naphthoxy)acetophenone after recrystallization from a dichloromethane-petroleum ether mixture.

출처 및 근거

ORD 기록
ord-bf48fa7d40fa410cb77be9c23de72d02
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04128659

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