Acetonitrile → Ranisen

HRID 65765

반응식

HRID 65765 반응식
[CH3:1][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][NH2:14])=[CH:7][CH:6]=1)[CH3:3].CS[C:17](SC)=[CH:18][N+:19]([O-:21])=[O:20].[C:24](#[N:26])C>>[CH3:3][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:17]([NH:26][CH3:24])=[CH:18][N+:19]([O-:21])=[O:20])=[CH:7][CH:6]=1)[CH3:1]

참가 물질

4

반응물 3

HCID 6342AcetonitrileHCID 836231,1-Bis(methylthio)-2-nitroethyleneHCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine

생성물 1

HCID 5039Ranisen

실험 절차

2-[[[5-(Dimethylamino)methyl-2-furanyl]methyl]thio]ethanamine (4.25 g) and 1,1-bis(methylthio)-2-nitroethene (3.3 g) were refluxed in acetonitrile (50 ml) for 14 hr. Solvent was removed and the residue dissolved in 36% methanolic methylamine (50 ml) and the solution refluxed for 8 hr. Solvents were removed and the residue in methanol treated with charcoal. Filtration and evaporation of the solvent gave the title compound as Example 15 (5.0 g).

후처리

  1. customSolvent was removed
  2. dissolutionthe residue dissolved in 36% methanolic methylamine (50 ml)
  3. temperaturethe solution refluxed for 8 hr
  4. customSolvents were removed
  5. additionthe residue in methanol treated with charcoal
  6. filtrationFiltration and evaporation of the solvent

출처 및 근거

ORD 기록
ord-590ae28d589b41ae960292662b4c4b89
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04128658

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