Hydrogen Bromide → 2-Chloro-4-(4-hydroxyphenyl)pyridine hydrobromide

HRID 657667노트

반응식

HRID 657667 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([O:14]C)=[CH:10][CH:9]=2)[CH:5]=[CH:4][N:3]=1.[BrH:16]>>[BrH:16].[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:9]=[CH:10][C:11]([OH:14])=[CH:12][CH:13]=2)[CH:5]=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 260Hydrogen BromideHCID 534408782-Chloro-4-(4-methoxyphenyl)pyridine

생성물 1

HCID 1363359722-Chloro-4-(4-hydroxyphenyl)pyridine hydrobromide

실험 절차

A mixture of 2-chloro-4-(4-methoxyphenyl)pyridine (4.6 g) and 48% aqueous hydrobromic acid solution is heated under reflux for 3.5 hours and allowed to cool back to room temperature. The precipitate that appears is separated by filtration, washed with water and dried under reduced pressure to give 4.9 g of 2-chloro-4-(4-hydroxyphenyl)pyridine hydrobromide as a yellow solid used without further purification.

후처리

  1. temperatureis heated
  2. temperatureunder reflux for 3.5 hours
  3. customThe precipitate that appears is separated by filtration
  4. washwashed with water
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-8f8d494fbdab474f8a02b5649782bc73
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08076329B2

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