Isopropyl Acetate → 2-Methoxypyrimidine-5-carboxaldehyde
반응식
S(O)(O)(=O)=O.[CH3:6][O:7][C:8](=[NH:10])[NH2:9].C[O:12][C:13](=N)N.C[NH+]([CH2:19][C:20](CN(C)C)=[CH:21][NH+](C)C)C.C(OC(C)C)(=O)C.C(=O)(O)[O-].[K+]>O>[CH3:6][O:7][C:8]1[N:9]=[CH:21][C:20]([CH:13]=[O:12])=[CH:19][N:10]=1참가 물질
6
실험 절차
To a stirred slurry of O-methylisourea hemisulfate (1.08 g, 4.13 mmol), vinamidinium salt (3.00 g, 8.26 mmol), 1-methylethyl acetate (16.0 mL, 137 mmol) was added a solution of potassium bicarbonate (1.17 g, 11.6 mmol) in water (5.0 mL) over a 10 minutes period. After completion of the addition the resulting reaction mixture was stirred at room temperature for 40 hours. The mixture was diluted with water (20 mL) and extracted with EtOAc (2×25 mL). The combined organic layers were dried over sodium sulfate and concentrated to yield a white solid.
후처리
- additionAfter completion of the addition
- customthe resulting reaction mixture
- extractionextracted with EtOAc (2×25 mL)
- dry with materialThe combined organic layers were dried over sodium sulfate
- concentrationconcentrated
- customto yield a white solid
출처 및 근거
- ORD 기록
- ord-fe6c5ecaa1a94111831f0dae382a8cf6
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08076345B2
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